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Basic concepts in medicinal chemistry / Marc W. Harrold

By: Harrold, Marc W [author]Material type: Text

TextPublication details: Bethesda, MD : American Society of Health-System Pharmacists, c2018Edition: Second editionDescription: xii, 606 pages : illustrations ; 26 cmISBN: 9781585286010Subject(s): PHARMACEUTICAL CHEMISTRY | LOC classification: RS 403 .H37 2018

Contents:

Functional group characteristics and roles -- Identifying acidic and basic functional groups -- Solving pH and pKa problems -- Salts and solubility -- Drug binding interactions -- Stereochemistry and drug action -- Drug metabolism -- Structure activity relationships and basic concepts in drug design -- Whole molecule drug evaluation

Summary: Medicinal chemistry is a complex topic. Written in an easy to follow and conversational style, Basic Concepts in Medicinal Chemistry focuses on the fundamental concepts that govern the discipline of medicinal chemistry as well as how and why these concepts are essential to therapeutic decisions. The book emphasizes functional group analysis and the basics of drug structure evaluation. In a systematic fashion, learn how to identify and evaluate the functional groups that comprise the structure of a drug molecule and their influences on solubility, absorption, acid/base character, binding interactions, and stereochemical orientation. Relevant Phase I and Phase II metabolic transformations are also discussed for each functional group.

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Item type	Current library	Home library	Collection	Shelving location	Call number	Copy number	Status	Date due	Barcode
Books	National University - Manila	National University - Manila	Pharmacy	General Circulation	GC RS 403 .H37 2018 (Browse shelf (Opens below))	c.1	Available		NULIB000016529

Includes index.

Functional group characteristics and roles --
Identifying acidic and basic functional groups --
Solving pH and pKa problems --
Salts and solubility --
Drug binding interactions --
Stereochemistry and drug action --
Drug metabolism --
Structure activity relationships and basic concepts in drug design --
Whole molecule drug evaluation

Medicinal chemistry is a complex topic. Written in an easy to follow and conversational style, Basic Concepts in Medicinal Chemistry focuses on the fundamental concepts that govern the discipline of medicinal chemistry as well as how and why these concepts are essential to therapeutic decisions. The book emphasizes functional group analysis and the basics of drug structure evaluation.

In a systematic fashion, learn how to identify and evaluate the functional groups that comprise the structure of a drug molecule and their influences on solubility, absorption, acid/base character, binding interactions, and stereochemical orientation. Relevant Phase I and Phase II metabolic transformations are also discussed for each functional group.

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