Handbook of basic pharmacokinetics-- including clinical applications / Wolfgang A. Ritschel

By: Ritschel, Wolfgang A [author]Material type: TextTextPublication details: Hamilton, IL. : Drug Intelligence Publications, c1992Edition: Fourth editionDescription: v, 588 pages : illustrations ; 18 cmISBN: 0914768506Subject(s): PHARMACOKINETICS -- HANDBOOKS, MANUALS, ETC | CHEMISTRY, PHARMACEUTICAL | BIOPHARMACEUTICS | PHARMACOLOGYLOC classification: RM 301.5 .R58 1992
Contents:
Definitions and glossary -- LADMER system-drug liberation, absorption, distribution, metabolism, elimination and response -- Organs, tissues, cells and organelles -- Cell membranes: structure, functions and properties -- Drug receptor interactions -- Absorption/transport mechanisms -- pKa and degree of ionization -- Lipid/water partition coefficient -- Physico-chemical factors altering biological performance of drugs -- Biopharmaceutical data of the gastrointestinal tract -- Fluid compartments and circulatory system (blood and lymph) -- Binding of drugs to biological material -- Drug metabolism -- Compartment models -- Determination of rate constants -- Volume of distribution and distribution coefficient -- Excretion and clearance of drugs -- Urinary and biliary recycling -- Cumulative urinary excretion -- Area under the blood level-time curve -- Pharmacokinetics of single dose administration -- Pharmacokinetics of multiple dosing -- Compartment model independent analysis -- Drug dosage in children -- Drug dosage in elderly patients -- Drug dosage in obese patients -- Drug dosage in pregnancy. (cont) Dosage regimen design -- Drug monitoring and dose adjustment -- Physiological and pathological factors influencing drug response -- First dose size in man -- Forensic pharmacokinetics -- Nonlinear pharmacokinetics -- Curve fitting -- Correlation of clinical response with drug disposition -- Bioavailability and bioequivalence -- Body surface area.
Summary: Pharmacokinetics, a comparatively young discipline among the health sciences, is interrelated with biopharmaceutics, pharmacology, and therapeutics.
Item type: Books - Reference
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National University - Manila
Nursing Reference REF RM 301.5 .R58 1992 (Browse shelf (Opens below)) c.1 Available NULIB000015250

Includes bibliographical references and index.

Definitions and glossary --
LADMER system-drug liberation, absorption, distribution, metabolism, elimination and response --
Organs, tissues, cells and organelles --
Cell membranes: structure, functions and properties --
Drug receptor interactions --
Absorption/transport mechanisms --
pKa and degree of ionization --
Lipid/water partition coefficient --
Physico-chemical factors altering biological performance of drugs --
Biopharmaceutical data of the gastrointestinal tract --
Fluid compartments and circulatory system (blood and lymph) --
Binding of drugs to biological material --
Drug metabolism --
Compartment models --
Determination of rate constants --
Volume of distribution and distribution coefficient --
Excretion and clearance of drugs --
Urinary and biliary recycling --
Cumulative urinary excretion --
Area under the blood level-time curve --
Pharmacokinetics of single dose administration --
Pharmacokinetics of multiple dosing --
Compartment model independent analysis --
Drug dosage in children --
Drug dosage in elderly patients --
Drug dosage in obese patients --
Drug dosage in pregnancy. (cont) Dosage regimen design --
Drug monitoring and dose adjustment --
Physiological and pathological factors influencing drug response --
First dose size in man --
Forensic pharmacokinetics --
Nonlinear pharmacokinetics --
Curve fitting --
Correlation of clinical response with drug disposition --
Bioavailability and bioequivalence --
Body surface area.

Pharmacokinetics, a comparatively young discipline among the health sciences, is interrelated with biopharmaceutics, pharmacology, and therapeutics.

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