Handbook of basic pharmacokinetics-- including clinical applications / Wolfgang A. Ritschel
Material type:

Item type | Current library | Home library | Collection | Shelving location | Call number | Copy number | Status | Date due | Barcode |
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LRC - Main | National University - Manila | Nursing | Reference | REF RM 301.5 .R58 1992 (Browse shelf (Opens below)) | c.1 | Available | NULIB000015250 |
Includes bibliographical references and index.
Definitions and glossary --
LADMER system-drug liberation, absorption, distribution, metabolism, elimination and response --
Organs, tissues, cells and organelles --
Cell membranes: structure, functions and properties --
Drug receptor interactions --
Absorption/transport mechanisms --
pKa and degree of ionization --
Lipid/water partition coefficient --
Physico-chemical factors altering biological performance of drugs --
Biopharmaceutical data of the gastrointestinal tract --
Fluid compartments and circulatory system (blood and lymph) --
Binding of drugs to biological material --
Drug metabolism --
Compartment models --
Determination of rate constants --
Volume of distribution and distribution coefficient --
Excretion and clearance of drugs --
Urinary and biliary recycling --
Cumulative urinary excretion --
Area under the blood level-time curve --
Pharmacokinetics of single dose administration --
Pharmacokinetics of multiple dosing --
Compartment model independent analysis --
Drug dosage in children --
Drug dosage in elderly patients --
Drug dosage in obese patients --
Drug dosage in pregnancy. (cont) Dosage regimen design --
Drug monitoring and dose adjustment --
Physiological and pathological factors influencing drug response --
First dose size in man --
Forensic pharmacokinetics --
Nonlinear pharmacokinetics --
Curve fitting --
Correlation of clinical response with drug disposition --
Bioavailability and bioequivalence --
Body surface area.
Pharmacokinetics, a comparatively young discipline among the health sciences, is interrelated with biopharmaceutics, pharmacology, and therapeutics.
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