Biopharmaceutics modeling and simulations : theory, practice, methods, and applications / Kiyohiko Sugano
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TextPublication details: Hoboken, N.J., Chichester : Wiley-Blackwell ; John Wiley [distributor], c2012Description: xxxv, 483 pages : illustrations ; 24 cmISBN: - 9781118028681
- RM 301.4 .S85 2012
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National University - Manila | LRC - Main General Circulation | Pharmacy | GC RM 301.4 .S85 2012 (Browse shelf(Opens below)) | c.1 | Available | NULIB000007349 |
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| GC RM 301.4 .S53 2012 c.1 Applied biopharmaceutics and pharmacokinetics / | GC RM 301.4 .S53 2012 c.2 Applied biopharmaceutics and pharmacokinetics / | GC RM 301.4 .S53 2012 c.3 Applied biopharmaceutics and pharmacokinetics / | GC RM 301.4 .S85 2012 Biopharmaceutics modeling and simulations : theory, practice, methods, and applications / | GC RM 301.5 .B87 2006 Applied pharmacokinetics & pharmacodynamics : principles of therapeutic drug monitoring / | GC RM 301.5 .C87 2017 Introduction to drug disposition and pharmacokinetics / | GC RM 301.5 .D57 2010 Concepts in clinical pharmacokinetics / |
Includes bibliographical references and index.
Introduction -- Theoretical framework I : solubility -- Theoretical framework II : dissolution -- Theoretical framework III : biological membrane permeation -- Theoretical framework IV : gastrointestinal transit models and integration -- Physiology of gastrointestinal tract and other administration sites in humans and animals -- Drug parameters -- Validation of mechanistic models -- Bioequivalence and biopharmaceutical classification system -- Dose and particle size dependency -- Enabling formulations -- Food effect -- Biopharmaceutical modeling for miscellaneous cases -- Intestinal transporters -- Strategy in drug discovery and development -- Epistemology of biopharmaceutical modeling and good simulation practice
A comprehensive introduction to using modeling and simulation programs in drug discovery and development Biopharmaceutical modeling has become integral to the design and development of new drugs. Influencing key aspects of the development process, including drug substance design, formulation design, and toxicological exposure assessment, biopharmaceutical modeling is now seen as the linchpin to a drug's future success.
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