Revised edition of: Biochemistry / Victor L. Davidson, Donald B. Sittman. 3rd ed. c1994.

Includes bibliographical references and index.

Preface xi
Acknowledgments xiii
Section I Structure and Function of the Major Cell Components
Water, Acid--Base Equilibria, and Blood pH
1 (10)
Water
1 (1)
Acid--base equilibrium
2 (3)
Regulation of blood pH
5 (6)
Amino Acid and Protein Structure
11 (18)
Nature of proteins
11 (1)
Amino acids
12 (3)
Peptides and polypeptides
15 (1)
Conformation of proteins
16 (3)
Purification of proteins
19 (10)
Protein Structure--Function Relationships
29 (30)
Introduction
29 (1)
Oxygen transport proteins
29 (9)
Albumin
38 (1)
Humoral immunity
39 (3)
Collagen
42 (6)
Muscle contraction
48 (11)
Enzymes
59 (18)
General characteristics of enzymes
59 (1)
Mechanism of enzyme catalysis
60 (1)
Enzyme kinetics
61 (2)
Enzyme inhibition
63 (2)
Regulation of enzymes
65 (1)
Enzymes in clinical diagnosis
66 (1)
Blood clotting
67 (3)
Regulation of clotting
70 (1)
Drugs that affect clotting
71 (6)
Carbohydrate Function and Structure
77 (12)
Carbohydrate functions
77 (1)
Carbohydrate classification and nomenclature
77 (1)
Structures
78 (1)
Glycosidic linkages
79 (2)
Carbohydrate derivatives
81 (1)
Glycoproteins
81 (2)
Blood group antigens
83 (6)
Nucleic Acids
89 (16)
Nucleic acids are polymers of nucleotides
89 (2)
DNA secondary structure
91 (5)
Higher order (tertiary) structure of DNA
96 (2)
RNA structure
98 (7)
Lipids and Related Compounds
105 (14)
Nature of lipids
105 (1)
Fatty acids
105 (2)
Phospholipids
107 (1)
Sphingolipids
108 (1)
Eicosanoids
109 (3)
Steroids
112 (2)
Plasma lipoproteins
114 (5)
Section II Storage and Expression of Genetic Information
DNA Replication and Repair
119 (26)
The structure of DNA reveals a mechanism for its replication
119 (1)
Prokaryotic replication
119 (7)
Eukaryotic replication
126 (4)
Drugs that affect replication
130 (2)
Mutations
132 (2)
DNA repair
134 (11)
RNA Synthesis and Processing
145 (20)
Major classes of ribonucleic acid (RNA)
145 (2)
Transcription
147 (7)
Post-transcriptional RNA processing
154 (11)
Translation of mRNA: Protein Synthesis
165 (20)
Introduction
165 (1)
Activation of amino acids: formation of aminoacyl-transfer RNAs (tRNAs)
166 (1)
Codon--anticodon recognition
167 (2)
Structure of ribosomes
169 (1)
Protein synthesis in prokaryotes
170 (5)
Protein synthesis in eukaryotes
175 (2)
Protein synthesis on the endoplasmic reticulum
177 (1)
Drugs and inhibitors of protein synthesis in eukaryotes
178 (7)
Recombinant DNA
185 (22)
Introduction
185 (1)
Tools of recombinant DNA
185 (2)
Cloning
187 (8)
Major analytic techniques
195 (12)
Regulation of Gene Expression
207 (28)
Prokaryotes: the operon model for the regulation of gene expression
207 (3)
General control of operons
210 (2)
Control by attenuation
212 (3)
Introduction to regulation of gene expression in eukaryotes
215 (1)
Transcriptional regulation
215 (3)
Post-transcriptional regulation
218 (3)
Translational regulation
221 (1)
Alterations in gene content or position
222 (13)
Section III Metabolism
Introduction to Metabolism
235 (12)
Metabolism
235 (1)
Compartmentalization of metabolic pathways in cells
235 (3)
Bioenergetics
238 (1)
High-energy phosphate compounds
239 (1)
Oxidation--reduction reactions
240 (2)
Monitoring metabolic events in tissues
242 (5)
Vitamins and Minerals
247 (12)
Overview
247 (1)
Water-soluble vitamins
248 (4)
Fat-soluble vitamins
252 (2)
Minerals
254 (5)
Mechanisms of Hormone Action
259 (14)
Overview
259 (1)
Hydrophilic hormones
260 (5)
Lipophilic hormones
265 (8)
Glycolysis
273 (14)
Overview of glycolysis
273 (1)
Carbohydrate digestion
273 (2)
Embden-Meyerhof pathway (glycolysis)
275 (3)
ATP production
278 (2)
Disorders associated with impaired glycolysis
280 (1)
Fates of pyruvate
280 (1)
Lactic acidosis
281 (6)
Alternative Pathways of Carbohydrate Metabolism
287 (14)
Pentose phosphate pathway (hexose monophosphate shunt)
287 (2)
Uronic acid pathway (glucuronic acid cycle)
289 (1)
Metabolism of fructose
289 (3)
Metabolism of galactose
292 (1)
Sorbitol metabolism in diabetes
293 (1)
Formation of amino sugars
293 (1)
Ethanol metabolism
293 (8)
Pyruvate Dehydrogenase and Citric Acid Cycle
301 (10)
The pyruvate dehydrogenase (PDH) enzyme complex
301 (2)
Overview of the citric acid cycle
303 (1)
Reactions of the citric acid cycle
304 (2)
Anaplerotic reactions
306 (5)
Mitochondrial Electron Transport and Oxidative Phosphorylation
311 (12)
The electron transport (respiratory) chain
311 (3)
Oxidative phosphorylation
314 (2)
Coupling of phosphorylation to respiration
316 (1)
Disorders of mitochondrial oxidative phosphorylation
316 (1)
Superoxide metabolism
317 (6)
Gluconeogenesis
323 (10)
Overview of gluconeogenesis
323 (1)
Substrates for gluconeogenesis
323 (2)
Reactions of gluconeogenesis
325 (2)
Diseases associated with defects of gluconeogenesis
327 (1)
Control of gluconeogenesis
328 (5)
Glycogen Metabolism
333 (10)
Glycogen
333 (1)
Glycogenesis
333 (2)
Glycogenolysis
335 (1)
Phosphorylation cascades
335 (2)
Regulation of glycogen metabolism
337 (1)
Glycogen storage diseases
337 (6)
Fatty Acid Metabolism
343 (14)
Biosynthesis of fatty acids
343 (3)
Fatty acid oxidation
346 (3)
Triacylglycerols (triglycerides)
349 (2)
Ketone body metabolism
351 (6)
Metabolism of Lipids and Related Compounds
357 (16)
Metabolism of phosphoglycerides
357 (2)
Metabolism of sphingolipids
359 (1)
Metabolism of eicosanoids
360 (1)
Steroid metabolism
361 (4)
Lipoprotein metabolism
365 (8)
Amino Acid Degradation
373 (16)
Proteolysis
373 (2)
Amino acid pool
375 (1)
Metabolic flow of amino acid nitrogen
376 (3)
Classification of amino acids
379 (1)
Fate of carbon skeletons
379 (5)
Inherited disorders of amino acid catabolism
384 (5)
Biosynthesis of Amino Acids and Amino Acid--Derived Compounds
389 (14)
Biosynthesis of amino acids
389 (1)
Amino acids as major inputs to the one-carbon pool
390 (2)
Tyrosine-derived biologically important compounds
392 (2)
Tryptophan-derived biologically important compounds
394 (1)
Glutathione
395 (1)
Biosynthesis of other amino acid--derived compounds
395 (1)
Heme metabolism
396 (7)
Nucleotide Metabolism
403 (22)
Synthesis of purine and pyrimidine nucleotides
403 (7)
Deoxyribonucleotides
410 (1)
Degradation of purine and pyrimidine nucleotides
411 (2)
Biosynthesis of nucleotide coenzymes
413 (2)
Inhibitors of purine and pyrimidine metabolism
415 (3)
Diseases associated with defects of nucleotide metabolism
418 (7)
Integration of Metabolism
425 (12)
Metabolic fuels
425 (1)
Use of metabolic fuels
425 (3)
The flow of key metabolic intermediates between different pathways
428 (1)
Metabolism of specialized tissues
428 (3)
Adaptations during starvation
431 (1)
Diabetes mellitus
431 (6)
Comprehensive Exam 437 (28)
Index 465

NMS Biochemistry, Fourth Edition, is designed to help medical students successfully complete a course in biochemistry and prepare for USMLE Step 1. This new edition has been significantly updated, and extensively rewritten to emphasize medical relevance.