000			01692nam a2200229Ia 4500
003			NULRC
005			20250520102854.0
008			250520s9999 xx 000 0 und d
020			_a812113462
040			_cNULRC
050			_aRM 301.4 .G53 1991
100			_aGibaldi, Milo _eauthor
245		0	_aBiopharmaceutics and clinical pharmacokinetics / _cMilo Gibaldi
250			_aFourth edition.
260			_aPhiladelphia, Pennsylvania : _bLea & Febiger, _cc1991
300			_ax, 406 pages : _billustrations ; _c27 cm.
504			_aIncludes bibliographical references and index.
505			_aIntroduction to pharmacokinetics -- Compartmental and noncompartmental pharmacokinetics -- Gastrointestinal absorption--biologic considerations -- Gastrointestinal absorption--physicohemical considerations -- Gastrointestinal absorption--role of the dosage forms -- Nonoral medication -- Prolonged-release medication -- Bioavailability -- Drug concentration and clinical response -- Drug disposition--distribution -- Drug disposition--elimination -- Pharmacokinetic variability-- body weight, age, sex, and generic factors -- Pharmacokinetic variability--disease -- Pharmacokinetic variability--drug interactions -- Individualization and optimization of drug dosing regiments
520			_aThis updated introduction to the clinical applications of pharmacokinetics looks at gastrointestinal absorption, prolonged release medication, and drug disposition. The effects of disease, weight, age, sex and genetic factors on pharmacokinetic variability and drug response are detailed. Bioequivalence and regulatory considerations for generic drug.
650			_aBIOPHARMACEUTICS
942			_2lcc _cBK
999			_c17518 _d17518