000			03080nam a2200241Ia 4500
003			NULRC
005			20250520094919.0
008			250520s9999 xx 000 0 und d
020			_a471190950
040			_cNULRC
050			_aQD 253 .S65 1998
100			_aSolomons, T. W. Graham. _eauthor
245		0	_aOrganic chemistry / _cT W Graham Solomons and Craig B Fryhle
250			_aSeventh edition.
260			_aNew York : _bWiley, _cc2000
300			_a1 volume (various pagings) : _bcolor illustrations ; _c27 cm.
504			_aIncludes bibliographical references and index.
505			_aCarbon compounds and chemical bonds -- Representative carbon compounds: funtional groups, intermolecular forces, and infrared (IR) spectroscopy -- An introduction to organic reactions: acids and bases -- Alkanes: nomenclature, conformational analysis, and an introduction to synthesis -- Stereochemistry: chiral molecules -- Ionic reactions--nucleophilic substitution and elimination reactions of alkyl halides -- Alkenes and alkynes I: properties and synthesis. Elimination reactions of alkyl halides -- Alkenes and alkynes II: addition reactions -- Nuclear magnetic resonance and mass spectrometry: tools for structure determination -- Radical reactions -- Alcohols and ethers -- Alcohols from carbonyl compounds. Oxidation--reduction and organometallic compounds -- Conjugated unsaturated systems -- Aromatic compounds -- Reactions of aromatic compounds. Aldehydes and ketones I: nucleophilic addition to the carbonyl group -- Aldehydes and ketones II. aldol reactions -- Carboxylic acids and their derivatives. Nucleophilic addition-elimination at the acyl carbon -- Synthesis and reactions of B-dicarbonyl compounds: more chemistry of enolate ions -- Amines -- Phenols and aryl halides: nucleopholic aromatic substitution -- Carbohydrates -- Lipids -- Amino acids and proteins -- Nucleic acids and protein synthesis.
520			_aOn the cover of this book is a Pacific yew tree, found in the ancient forests of the Pacific Northwest. The bark of the Pacific yew tree produces Taxol, found to be a highly effective drug against ovarian and breast cancer. Taxol blocks mitosis during eukaryotic cell division. The supply of Taxol from the Pacific yew tree is vanishingly small, however. A single 100-year-old tree provides only about one dose of the drug (roughly 300 mg). For this reason, as well as the spectacular molecular architecture of Taxol, synthetic organic chemists fiercely undertook efforts to synthesize it. Five total syntheses of Taxol have thus far been reported. Now, a combination of isolation of a related metabolite from European yew needles, and synthesis of Taxol from that intermediate, supply the clinical demand. This case clearly demonstrates the importance of synthesis and the use of organic chemistry. It's just one of the many examples used in the text that will spark the interest of students and get them involved in the study of organic chemistry!
650			_aCHEMISTRY, ORGANIC
700			_aFryhle, Craig B. _eco-author
942			_2lcc _cBK
999			_c6114 _d6114