000			01885nam a2200229Ia 4500
003			NULRC
005			20250520100622.0
008			250520s9999 xx 000 0 und d
020			_a9781118028681
040			_cNULRC
050			_aRM 301.4 .S85 2012
100			_aSugano, Kiyohiko _eauthor
245		0	_aBiopharmaceutics modeling and simulations : _btheory, practice, methods, and applications / _cKiyohiko Sugano
260			_aHoboken, N.J., Chichester : _bWiley-Blackwell ; John Wiley [distributor], _cc2012
300			_axxxv, 483 pages : _billustrations ; _c24 cm.
365			_bUSD125.99
504			_aIncludes bibliographical references and index.
505			_aIntroduction -- Theoretical framework I : solubility -- Theoretical framework II : dissolution -- Theoretical framework III : biological membrane permeation -- Theoretical framework IV : gastrointestinal transit models and integration -- Physiology of gastrointestinal tract and other administration sites in humans and animals -- Drug parameters -- Validation of mechanistic models -- Bioequivalence and biopharmaceutical classification system -- Dose and particle size dependency -- Enabling formulations -- Food effect -- Biopharmaceutical modeling for miscellaneous cases -- Intestinal transporters -- Strategy in drug discovery and development -- Epistemology of biopharmaceutical modeling and good simulation practice
520			_aA comprehensive introduction to using modeling and simulation programs in drug discovery and development Biopharmaceutical modeling has become integral to the design and development of new drugs. Influencing key aspects of the development process, including drug substance design, formulation design, and toxicological exposure assessment, biopharmaceutical modeling is now seen as the linchpin to a drug's future success.
650			_aBIOPHARMACEUTICS
942			_2lcc _cBK
999			_c9590 _d9590