000			02548nam a2200229Ia 4500
003			NULRC
005			20250520100622.0
008			250520s9999 xx 000 0 und d
020			_a9780748404148
040			_cNULRC
050			_aRA 1191 .A43 1996
100			_aAldridge, W. Norman. _eauthor
245		0	_aMechanisms and concepts in toxicology / _cW. Norman Aldridge
260			_aLondon, United Kingdom : _bTaylor & Francis, _cc1996
300			_axi, 254 pages : _billustrations ; _c26 cm.
365			_bUSD121.05
504			_aIncludes bibliographical references (pages 218-247) and index.
505			_a1. Scope of Toxicology -- 2. Stages in the Induction of Toxicity -- 3. Kinetics and End-points -- 4. Acute and Chronic Intoxication -- 5. Delivery of Intoxicant: Decrease in delivery to the target -- 6. Delivery of Intoxicant: Bioactivation and increase in delivery to the target -- 7. Initiating Reactions with Targets -- 8. Biological Consequences of Initiating Reactions with Targets -- 9. Exposure, Dose and Chemical Structure, Response and Activity, and Thresholds -- 10. Selective Toxicity, Animal Experimentation and In Vitro Methods -- 11. Biomonitoring -- 12. Epidemiology -- 13. Environmental and Ecotoxicology -- 14. Reflections, Research and Risk.
520			_aAn erroneous perception of risk from exposure to chemicals is that it is higher than other risks to which we are subject; it is also believed that exposure to synthetic chemicals is more hazardous than exposure to natural toxins that are present in air, water, plants and animals. This book, by clarifying the principles that apply to all chemicals and all organisms, including humans, explains why some chemicals are toxic and others are not, why different classes of chemicals cause different illnesses and why low exposures are usually harmless.The focus of Mechanisms and Concepts in Toxicology is on research procedures. Mechanistic research in toxicology leads not only to a greater understanding of the biology involved, but also the means to design substances with selectivity between species and minimal undesirable side-effects. The book develops a framework for understanding intoxication by chemicals. Five stages are described - exposure, delivery of intoxicant to its site of action, events that initiate the intoxication, early biological consequences and clinical findings. For each stage, mechanisms, concepts and keywords are defined and illustrated with examples of specific chemical intoxicants.
650			_aTOXICOLOGY
942			_2lcc _cBK
999			_c9591 _d9591